(Restricted Access Barriers)
Open passive RABS utilise existing clean room overhead air supply systems to deliver HEPA-filtered air over the particle process before returning air back into the clean room. In an open active RABS onboard fan/filtration units supply HEPA-filtered air over the critical process before returning air back to the clean room. In open RABS, the enclosure is not sealed to the equipment.
Open RABS (oRABS) are useful to increase product protection, but they are not useful with toxic products, since they cannot offer any type of protection for the operator and the environment.
Closed RABS (cRABS) is a positive pressure system with onboard fan/filtration units to supply HEPA-filtered air over the critical process before being recirculated. All RABs can include glove ports, RTP systems, access doors with interlocks and EM systems.
Due to the lack of leak-tight certification, these systems can not be used for highly toxic products.
Also, these systems must assure a class A environment, and the surrounding must be classified as B.
As described before the use of Isolation Technology allows the installation of a vial/syringe filling line for aseptic products in a production area classified as Class C, instead of a Class B that is requires when a Open RABS or a Closed RABS is used.
The downgrade of the classification of the production room allows the following Operation Cost savings:
The adoption of an Open or Closed RABS will allow reducing the AIR Handling costs by approx. 35%, compared with an installation in a conventional clean room.
Contact Brinda Pharma, Ahmedabad, India, today for all your RABS needs, including Open RABS (oRABS) and Closed RABS (cRABS). Our state-of-the-art barrier systems provide a safe and sterile manufacturing environment, ensuring product quality and safety. Trust us to provide you with an efficient and effective solution. Get in touch with us now!